We say it with a segol as it is in Artscrol Sidurim. The Chasam Sofer questions it should have said במאמרו? He answers that it refers to our abilities we can also accomplish with our mouths. To explain what he means, the targum on ויפח באפיו נשמת חיים, Hashem blew in him soul of life, says the ability to speak. Now if someone blews, he blews from himself. If Hashem has the abilities to create things with His mouth, then we should also be able to do that, but we have besmudged our mouths.
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