We change the composition of the flu vaccine annually through what is really an “informed guess” as to specific strains that might be the most prevalent 9 months in the future. Some years we achieve a relatively high 65–75 percent efficacy and other years its below 50 percent. The new Covid vaccines using the MRNA platform have achieved 90%+ efficacy and have shown high efficacy as new strains evolve. There will have to be tweeks to the booster shots just as we modify the flu shots annually using informed guesses as to which variants need to be protected against. Unlike business and school closures which have their own material adverse effects, there are virtually no down-sides to masking in combination with vaccination in high community transmission areas, unless of course, being unmasked becomes your symbol of resistance to the deep state and perverse desire to impose public health risks on yourself and others.
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