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September 25, 2021 11:53 pm at 11:53 pm
#2010011
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we do know some things now. So, look at early predictions and how they compare with later knowledge to estimate magnitude of errors and biases. For example, we had phase 3 results for vaccines and later much bigger observational studies. So, you can compare phase 3 results with observations under same conditions (original Wuhan and right after vaccine) – those were pretty on target both in safety and efficiency. and then, there are changes in conditions – Delta and 6 months later.