Your and you’re are two pet peeves of mine. I also notice quite often that people write loose (meaning not tight), when they mean LOSE (as in, where oh where can my car keys be?). ALSO, and goodness knows I really do not mean to sound critical, but I have seen this error repeatedly. It’s = it is. “Its” without an apostrophe, is the possessive non-gendered form for “belonging to.” Too often people will write the former when they mean the latter.
I wouldn’t say these errors make my bones twitch, but I do notice them…