Connecting to people. Connecting to Hashem. Having a self identity. Living selflessly, and understanding the value of self sacrifice. Although these aren’t specific Mitzvos, I think they all represent what has become nearly obsolete in today’s technological world. It’s a world filled with technology centered around making our lives easier, and bringing service faster and more efficiently. Middos are hard to maintain when we’ve become used to receiving what we want, when we want it.
So I would go with any Mitzva that is Bein Adam Lchaveiroh to combat out technology problem.
There is also a sense of publicizing everything and anything about ourselves and everyone that has become problematic today. I would therefore also go with any Mitzva that encourages privacy, such as not speaking Lashon Hora, and Tznius.
Who know’s what people will look back at and see as our struggle? Did they know that Shabbos would be seen as their biggest hardship to overcome?