I highly doubt Publisher is what you are looking for. I mean, it does have a right to left option, but besides for that, I don’t think it’s made for professional books. It’s more for basic cards and letters. And I don’t see how you can manipulate text boxes to turn and grow and shrink (like in Gemara, Sulchan Aruch ect.)
I don’t know and it seems like noone on YW ever printed a Sefer [we are all too busy wasting our lives here …]
Try to find someone in your community or BM that published a Sefer and ask him.
Hatzlacha!!
SiDi™