I see you’ve addressed this question directly to me, “those going crazy”. Been there (ever since) done that (oh yeah, and much more).
The first thing you can do is to extend a loving, caring arm. Physically and emotionally. Let her know you’re there for her whenever she should need support, assistance, comfort. How about letting you and her explore her unique admirable qualities. EVERYONE has. Let it shine out, let her friends be made aware to. Get her to be admired, loved, “in”. With caring, devotion, some exertion, it can be achieved. -my opinion. (again, you directed this solely to me)