Rabbi Akiva’s wife went against her parents wishes and we all know how that turned out. She earned eternal reward for helping to create one of the most dynamic Rabbunim in all of history.
But
As someone who has been married more than once I can tell you that there is tremendous friction when the in-laws don’t like you. Depending on your wife’s personality, it can ultimately cause the end of a marriage. Also , Do you really want to be part of a family that hates you?
I would advise you to not only speak to a trusted Rav, but a really good family therapist and get more than one opinion before proceeding.
Hatzlocho!