Rashi comments that the Shechinah left Yaakov because Ephraim and Menashe would have wicked descendants, and he did not want to bless them. Kli Yakar says that Yoseph asked Yaakov to bless them in any case, just as HaShem blessed Yitzchak although Eisav would descend from Him. But how can Yaakov be compared to HaShem? Indeed, Avraham did not bless Yitzchak because Eisav would descend from him (Rashi Bereishis 25:11).
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