Josh
I don’t claim to be an expert in kashrut, but a couple of points
In general , halacha ignores the microscopic.
You can drink water bc the microorganisms aren’t hallachically significant. Blights on an estrog are evaluated at arms length.
Chassidush poskim tend to be more machmir on this in regards to IVF and it’s status as a mamzir. But gene splicing should be considered kosher
As to your case of hybrid kosher animals created from treif DNA, you run into a separate problem of animals needing mesorah to be considered kosher.
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