C A, DV was a talmid who delved to deeply into the Force and was trapped by the Dark (Other) Side. It would be interesting to know if there was others. Perhaps one died and another went insane.
Yserbius, Obi-Wan Kenobi describes the Force as “an energy field created by all living things” in Star Wars. In The Phantom Menace, Qui-Gon Jinn says microscopic lifeforms called midi-chlorians, which exist inside all living cells, allow some characters to be Force-sensitive; characters must have a high enough midi-chlorian count to feel and use the Force [Wikipedia]. This sounds like a scientific principle to me.