Syag, simple reading is that Hashem would not give us mitzvos that can hurt us. And I am asking if someone could look up what is the definition of danger here.
There is definitely time for mesiras nefesh during the time of prosecution, but my sense of this Gemora is that Hashem does not give us mitzvos that their ordinary performance is bad for us. There are extra-ordinary examples of, say Rabbi Chaninah making the snake bite him and the snake dies, but I don’t think we are called to emulate him.