The rashba and tons of rishonim, achronim, say that even to aegue with chazals scientific statements would be apikorsus; the aruch hashulchan notes that too – kal vechomer midrashim. Sources for that are in rav moshe meiselman’s Torah chazal and science.
You’re playing around very liberally with something that gedolei rishonim and achronim say can make a person lose their olam haba.
There’s also a famous gemara about a drasha regarding yemos hamoshiach, which a talmid said was not physically possible. The rebbe showed him in the ocean that Hashem was preparing this phenomenon, and said that he (the talmid) only believes what his eyes see, and doesn’t have emunas chachamim – whereupon he was turned into a pile of bones.
That was an aggada teaching. Clearly, the rishonim who “argued” with medrash were simply saying another pshat, and not saying that chazal were wrong.