@kuvult 100%. Take the gestation period of a snake for example. Chazal says it’s 7 years. It’s just not. There are two choices, either Chazal was working with the knowledge of the time, and that was the scientific answer of the time, or they were trying to make an esoteric point and couched it in the scientific language of the day, even though they knew better, in order for it to be understandable to people.
You could say that there is some sort of snake that had that long of a gestation period that is now extinct, but there is no record of that and it is unlikely that such an anomaly would go unmentioned- The Gemara was written at a time when these things were studied.
Another example would be Ta’am. The walls of modern-day pots and pans are not going to absorb and expel flavor the way pots and pans 2000 years ago. Food molecules are too large to get absorbed into stainless steel to the amount Chazal say it does. But in regard to Halacha, it doesn’t matter. There is a concept called Halachik Ta’am, and it is negated by 1/60 mixture.