Separate notebook, each donation marked separately, with periodic adjustments for taxes (or tax refunds) and business expenses – I used to track pushke donations, but then I figured I do not want H’KBH to be so meticulous when He calculates my salary, so I stopped – most months I am able meet my obligations, but I always try to enter Rosh HaShanna with a zero balance on my obligations – for a long time I kept up with ma’aser, then things changed and I simply could not (we do not eat out, we do not wear fancy clothes, we do not have new “home electronics” or fancy cell phones) – thank G-d, things came around and I am now able to meet my obligations – I think of it as insurance – G-d keeps me employed so that I can give tzedakah – I mostly give to local mosdos, but I would estimate that 5-10% of my ma’aser goes to national (non-Jewish) medical research organizations such as cancer, etc. – we yidden get those diseases, too, so I feel obligated to assist in that reasearch