Of course! Historical and geographical factors lead to differences not just between Sfardim and Ashkenazim but between Ashkenazim themselves! Compare to the Torah Im Derech Eretz of German jewry to the philosophy of the Eastern European jews.
An issue was brought with me from a younger bachur. Raised Sfardic, he became perplexed over whether to continue to wear a black hat or not since his Saba told him in Iraq they never did. While I did tell him to ask one with more experience in the matter (like the Mashgiach), it seems that this cross-culturalism has only become abundant in the past fifty years or so in America where we live in closer contact.