JMO, Any city that has had the zchus of Daily or weekly Minyanim for over 2000 years consequtively has some kedusha.
Other than Tunis, I cant think of any other city that has had so many consequtive minyanim
(I dont know if there was Minyanim every week during WW II)
I do know that the Emperor Hadrian banned jews from Jerusalem and renamed the city Aeola Capitola so Jerusalem does not fit the bill
I dont think there are any jews in Falluja (Pumpeditha) anymore