We have several dilemmas here. Firstly, sakanah deserves no compromise. Secondly, it is heresy to claim that “Yayin yesamach levav enosh” is in any way related to getting drunk. Thirdly, the Gemoroh never says Chayav inish “lehishtaker” – it says l’ivsumai. This is clearly reference to a state of exaltation, not the loss of one’s mind. The pirushim in ad delo yoda do not include anything bordering on danger.
One must be fully aware of one’s tolerance. Drinking more than that is medically serious. Between alcohol poisoning, falling and other accidents, to the poor judgment to do things that create even greater danger to self and others (like driving and fighting), the excess carries massive risk.
Lastly, it is vital that we be able to look inside ourselves in a manner that is critical and brutally honest. Is our drinking only for the mitzvah, where we do not lose focus from the true simcha of nais Purim, or are we at least partially capitalizing on Purim for our annual “legitimized” opportunity to get drunk? Remember that HKB”H knows the real answer. If you are in denial, then do a cheshbon hanefesh, and see what you find. May as well have the edge before you view the real emes in beis din shel maaloh.