Hi!
Firstly, I’m sorry to hear that your mom needs to go through this now.
I know of a few people who wear synthetics. They do have easy maintenance. However, they are the ones that look most like wigs. I have never yet seen a natural looking synthetic wig.
If you want a really natural look, what they can often do to a wig is sew the hair in the front in backwards (from the inside of the net in the front as opposed to just from the outer side). What this accomplishes, is that the hair now seems to be coming directly from the scalp, instead of from the net. Ask whoever you go to about this option,as it can create the most natural appearance possible.
Good luck!
May she have a speedy recovery!