I don’t think anyone (carrying real weight) says they had a perfect knowledge of science. That would mean there’s nothing you don’t know even the price of tea in China.
The answer would be that either they didn’t state what they didn’t know in science, even if their knowledge on their great level was in some way limited. Or it’s only what was ruled in ????? ???? that had special Siyata Dishmaya.
Regardless Reb Shlomo Zalman Aurbach (in ???? ??’ ????? ???? ?????) held the other view is valid.