Reply To: Having kids while having a history of genetic disorder

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#924811
BSD
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rabbi_dr-fascinatimg question.

Chiskiyahu hamelech saw binivuah that he would give birth to menashe-who would be a choteh umachteh es harabim on a grand scale. He chose not to have children. Chiskiyahu got sick, and the navie came in to inform him that he would die as punishment for his sin of choosing to not procreate. Chiskiyahu did tshuvah and Menashe came from him ( and another son who was a great tzaddik)

Amram-the gadol hador- separated from his wife due to Paroh’s decree of killing all male children. His entire generation followed suit. He accepted Miriam’s rebuke and got back together with his wife Yocheved-knowing that the rest of klal yisroel would do the same. Moshe rebbeinu was saved, but countless other yidden willingly had children, knowing in advance that if it’s a boy, the infant would be thrown into the Nile and die by drowning-as indeed so many did.

I am curious to know what the din is and would it make a difference if they were already mikayem pru urvu. Also would the couple have the option of getting divorced in order to avoid this issue, especially if they can each get remarried to someone who is not a carrier.