The Rambam right at the beginning of Moreh Nevuchim explains at length that the tzelem eloykim refers to the mind of a person and to C”VS say that Hashem has a body.
The Nefesh Hachaim starts off explaining this pasuk and bases his whole sefer upon it.
??? ???? ??????? ???? ????. ??? ?????? ??????? ????? ?? ???? ???? ???? ??? ???? ??????? ?????. ???? ??? ???? ???? ??? ???? ??????? ???????? ?”? ?? ???? ???? ??? ?????? ???????:
Others add in that the pasuk is also referring to the body of a human which is made of 248 limbs corresponding to the mitzvos eseh. (By the way, I think that ???? ????? is gimatria 248 limbs)