Agree with verapei. I’m a 2nd year med student. Ii is quite fascinating. endotoxins during an infection causes your body to produce cytokines (il-1, il-6 etc.). They cross into the brain where they cause a release of arachidonic acid (through PLA2 which NSAIDS stop etc.)which ultimately are synthesized to PGE2. Now, he anterior portion of your hypothalamus is what stops your body from overheating. The PGE2 when created within the anterior hypothalamus , creates a higher thermoregulatory set-point. This helps your body fight the infection. However if it gets over 42 Celsius (about 107.6 F), that is hyperpyrexia that can cause coma and irreversibly damage your brain (cerebellar purkinje cell particularly susceptible). Over 43 Celsius, you can’t survive. (Should not be confused with Hyperthermia, which is when your body overheats, without a higher set-point. Really fascinating stuff. I’m waiting for Health’s to chime in with his/her’s expertise
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