Reply To: DNA testing and Halchah

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#997477

zahavasdad- You are thinking about a situation in which a mother that is Rh -ve and pregnant with her second baby that is Rh +ve (due to genetic information for the Rh factor being inherited from the father). The mother’s body will recognize the first baby’s Rh as a foreign antigen and immune memory will be established. When the second baby’s Rh antigen presents to the mother, an immune response will be mounted, with B-cells differentiating into plasma cells which produce IgG antibodies (The smallest of the immunoglobulins and therefore able to cross the placenta) against the red blood cells of the baby leading to a condition known as hemolytic disease of the newborn.