“About the only example I can think of is Rome where the Jewish Ghetto is right near the Vatican and the Colleseum. Even in NY the frum communities are in Brooklyn not really Manhattan”
There are frum communities and kosher restaurants in Paris all over the city — no eruv, though. And there are strong frum communities in many if not most Manhattan neighborhoods (not to mention many in Queens, The Bronx, and Staten Island!).
Other examples: There is an Orthodox synagogue with a small community within walking distance of the most popular tourist attractions in Philadelphia — in fact IT should be a tourist attraction as it is the oldest continuously operating synagogue in North America. There is an Orthodox synagogue with a small community within walking distance of Baltimore’s inner harbor. There is an Orthodox synagogue in the Georgetown section of Washington, DC with a strong community and its eruv includes all the major tourist attractions. I’m sure that there must be other examples.