This is the one borrowing Some Common Sense’s account.
WinnieThePooh – No, I don’t mind. Resveratrol seems to cause it’s antineoplastic effects in the G0/G1 – S phase transition via the induction of Caspase-3. The raw chemical has a very short half-life in circulation requiring gram doses to be effective in raw form. The glucuronidated form is more stable and has a greater Cmax resulting in a greater biological effect.
Mods – I wonder if there is a way to share emails. This is not the right forum for this discussion.
Ubiquitin – Your point is quite true. I was referring to medications such as vancomycin and aminoglycosides which individually dosed based on CrCl. The actual math behind the protocols is heavily based on various patient factors and an accurate CrCl is one of them. The situation you mentioned about an apart change in CrCl based on an increase in SCr become quite relevant.
Health – my comment was simply that neither group is incompetent. Each try to do their best but make mistakes. I don’t think that any prescriber tries to be incompetent no matter how it may seem to other people. But enough trivialities.
Sparky – 2-3 orgo-hard courses and 2 easier courses. Weekly exams. A teaching technique that is consistent with straight memorization but a testing format that demands application of said knowledge (oh and they never tell you how to apply what you learned plus many of the applications are based on the professor’s experience so you never really know if you have the right thought process). As Some Common Sense said, application is not something that many people are capable of in undergraduate study.