It absolutely depends on the person, their education, etc.
I went to a local secular college so as to avoid putting my parents in debt going to YU (then again YU didn’t offer my major, so it was just as well). I came out just as religious as when I went in, probably more so even. I lived at home and balanced work, a part-time to full-time job, a short evening seder and hobbies/free time. I also made it to shul 3x a day, 7 days a week. But this was some 15-20 years ago, when the current wave lunacy on college campuses was just beginning and could be called out for what it was.
In the current environment, I certainly would not send my kids to any college in the US, and not because of “pritzus” and it being “assur to fraternize with non-Jews”. The indoctrination and dumbing down of education is worse in my opinion and by themselves a reason to avoid it.
As a side point, those who will go OTD in college were likely already halfway there and looking for a way out.