Reply To: Hydroxychloroquine

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#1879528
ubiquitin
Participant

Health

I watched the interview I stand by my succinct assessment.

“In that interview, he actually discusses the definition of “Proving something”.
He has a different definition!”

I’m not sure if I saw the right interview (I saw the one with Del bigtree) He does nto really discuss the defitnion of “proving” He notes the idea that only Randomized controlled trials matter and rejects it saying why wait for those using a mashal of driftwood. I completely agree with Dr. Zelenko on this, there is a classic BMJ article from 2003 “Hazardous Journeys Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of randomized controlled trials” that criticizes the idea that only RCT matter.
If he thinks it works he should keep giving it. If any doctor thinks it works they should keep giving it. If a patient thinks it helps they should discuss it with their doctor, and if they dotnl iek the doctor’s answers they should get a new one. Thais has been my position since day one, and while the preponderance of data is indicating it does NOT work. The risk is minimal, and the data still inconclusive to say giving it is wrong.

The problem wit his study is NOT that it isnt a RCT. (reread my comments )

The problem is that his treatment group is not comparable to the general population
Look at his Group A in whcich he treated all aged > 60.
How many of them were over 70? zero!
In the general population how many of those older than 60 are older than 70?
About half (data from statista)
How many of them have COPd ? Zero!
How many of the general population > 60 has COPD ? About 10%

So his treatment group of thsoe > 60 are younger and healthier than the general population
Would it be any surprise that they outlived the general population when it comes to COVid 19?

and here is the real kicker….
His Data did not show statistical significance tha his younger healthier group who got HCQ+zn survived HCQ
The P value was no sginificant. the confidence interval crossed one.

This is why his study doesnt prove anythign (any way you defien prove) NOT that it wasnt A RCt.