Reply To: REALLY disappointing clinical trial results

Home Forums Decaffeinated Coffee REALLY disappointing clinical trial results Reply To: REALLY disappointing clinical trial results

#1910582

@CharlieHall, thanks for the reference. Trying to find some hopeful things here:

there seems to be a tendency across all to have better results for non-ventilated patients. Last column is 0.1-0.3 better for all 4 treatments. This is either a sign that treatments are more effective early or that early use of ventilators was not done properly.

THere is also variability by age: Remdesivir Ratio of Death Rates (<1 is good) is 0.91-0.93 for 2 groups over 50, Hydroxy 0.8 for 70+, lopinavir 90.77 for <50, interferon 0.9 for 70+
All these numbers are uncertain and each have maybe 30% chance of being > 1, but there is a possible hope here that positive results for subgroups are not random.

looking at most important group: 70+, most optimistic case of 3 treatments will be 0.65, if we unrealistically multiply all improvements. But given that this is a lower common denominator trial, one can see that further tweaking, early intervention, this would lead to 2x improvement.