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August 24, 2021 12:58 pm at 12:58 pm
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2scents, actually numbers you are quoting show some HCQ benefit across multiple studies. Even if each of them is below stat significance, they jointly will not be.
24% v 30% in placebo had symptoms
4 hospitalized v 8 or 10
1 died in both
0.27 events per year v 0.38
11.8 % v 14.3%
Cochrane review is a gold standard for meta-studies, trying to evaluate significance from multiple independent trials. Feb 2021 B Singh et al Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19 shows no benefit for HCQ in both treatment and prophylactics.