FDA advisors had a an interesting meeting on Friday discussing heterogeneous vaccines and their effect on antibody levels 1 month after booster.
notes (disclaimer: I am not a real doctor)
– J&J followed by mRNA gets to almost same high antibody level as mRNA booster (i.e. 3 total) – a month after booster, they are continuing observations. Delta included in this. Seems like J&J and mRNA gives much higher antibodies that two J&Js that were also approved Friday
– most heterogeneous results are same or better than doing same vaccine
– while J&J had lower antibody count than mRNA 1 month after, it kept the level 6 month later better
– they are not sure how B and T cells affect immunity in addition to antibodies.
– FDA would like to move very slow. Instead of asking a question “should we approve that”, they first asked “give us your ideas” and when pushed back, formulated a question “what additional information you would like to see”. The answers were mostly – this is good enough, stop asking us, just do full authorization, so that doctors could make free decisions instead of being afraid.
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