Sacrilege – You are absolutely right. Everyone has some genetic flaw. Hashem didn’t make us perfect. We just need to find someone who is “compatible” as DY so well puts it.
Reminds me of the Rabbi Twerski story where this man refused a shidduch for his son because the girl’s mother had a bout of depression. He told Rabbi Twerski, why should i introduce this gene in my family? Dr Twerski couldn’t tell him, due to patient confidentiality, that he had treated this man’s wife before she married him.