Cindy, every tzedakah comes with its own story. What are you most sincere about? Everyone chooses what is most important to them, and who they think needs the help the most. There are many organizations that beg for support and when you do your research, you find that they have tons of money from grants and government and wealthy supporters. And then there are others that really need every penny and give every penny to those in need.
So what is going on around you? Are there people out of work? Can you help with someone’s tuition? Can you help put food on someone’s table by donating to Tomchei Shabbos in your neighborhood? What about a Hachnosos Kallah fund? Is there a sick child in your area, or a particular tzedaka drive specific to your community? Charity begins at home, so take a good look what is happening right in front of you and that might help you decide