The sin’as chinam of the kamtza and bar kamtza story is what actually caused the destruction of the second beis hamikdash, historically speaking. I think the fact that Hashem allowed the events to play out in a way that this story was the cause, motivated the Chachamim to say that this was the reason as well. Not exactly like, but similar to the concept of ??????? ???? ?? ??? ???? ????? ?”? ????.
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