First of all good luck. I remember about 3 down turns ago when I was looking for my first job, it took a long time (and the job I ended up getting was lousy)
Second figure out what you want to do/be and make a plan. Don’t just send out thousands of Resumes and hope one of them hits. It might work but the odds are against you. What you want to do is network. Figure out where the people you want to work with meetup and go there. (meetup.com is your friend here) Get to know them, sooner or later with luck someone will know someone who needs whatever it is you can do.
Yea, its not easy at first but its the way it is. And be working on new skills constantly!