Heads are starting to roll at JPMorgan Chase in the wake of the bank�s staggering $2 billion trading loss.

Ina Drew, the global bank�s chief investment officer and one of the most powerful women on Wall Street, has reportedly resigned, along with two other top executives.

Drew, a close associate of bank president Jamie Dimon, ran the risk-management division that was responsible for the enormous losses. She made $15.5 million last year.

The Wall Street Journal said the other two ousted execs are Achilles Macris, who ran the London-based desk that placed the trades, and managing director Javier Martin-Artajo.

Bruno Michel Iksil, the French-born finacier nicknamed �Voldemort� and �the London Whale� who was directly responsible for the trades, was not reported to be on the list.

Dimon, who had dismissed concerns about the losses as a �tempest in a teapot,� was contrite and void of his typical swagger on Sunday.

�We made a terrible, egregious mistake that there is almost no excuse for,� he said on NBC�s Meet the Press.

The $2 billion in bad bets came from trading in credit derivatives in an effort to hedge against financial risk from the turmoil in Europe, not to make a profit.

�Hedging should make your bank less risky. In this particular case, we made a terrible mistake,� Dimon said.

He admitted that JPMorgan Chase�s errors had given the Obama administration new ammunition in the battle for more bank regulation to avoid another credit crisis.

�This is a very unfortunate and inopportune time to have had this kind of mistake,� he said.

Drew, 55, had repeatedly offered to resign since the scale of the loss became apparent in late April, executives at the bank told the Journal.

Dimon did not accept blame until Sunday – two days after the public disclosure of the losses sent JPMorgan�s plunging 9% and dragged down other financial stocks, sparking fears of a new market panic.

Dimon stressed on NBC that JPMorgan, America�s largest bank with $2.27 trillion in assets, is �very strong.� The bank emerged relatively unscathed from the 2008 financial crisis.

Dimon is not considered in trouble, but he may face tough questions about his 2011 $23 million pay package at Tuesday’s annual shareholder meeting.

(Source: NY Daily News)